Mass Spectrometry

Overview of Services

The MUSC Mass Spectrometry Facility provides expertise, services, education, and training to enhance biomedical research endeavors through LC-MS/MS-based proteomics. 


LC-MS/MS for quantitative proteomics to for differential protein abundance, identification of differentially expressed nascent proteins, protein-protein or protein-drug interactions, phosphoproteomics.                     

ThermoScientific Orbitrap Elite ETD Mass Spectrometer interfaced to an Ultimate 3000 nanoLC system.

  • For protein identification, characterization of post-translational modifications, and quantitative proteomics using SILAC, TMT/iTRAQ, and label free approaches.   
  • Acquired through the NIH Shared Instrumenation Grant Program: S10D010731 Orbitrap Elite ETD Mass Spectrometer.  Please cite and link the grant to your publications on MyNCBI Bibliography.



MALDI-TOF Mass Spectrometry for intact proteins or peptides.

Bruker Autoflex III MALDI-TOF

 Related image




Director:  Lauren E. Ball, Ph.D.; 843-792-4513,

Lab Manager:  Jennifer Bethard, M.S.; 843-792-8637,

Susana Comte-Walters, M.S.  

Kim Norris-Caneda, M.S.

Location and hours of operation

Hours Location

Available for consults Wednesday 1:00PM, CRI 311

To schedule

Proteomics Center

305 Children’s Research Institute

Charleston, SC 29425

Links and Resources

Redox Center:  SC Center of Biomedical Research Excellence in Oxidants, Redox Balance and Signaling (P20 GM103542, PI:Tew)‑ Proteomics Core (Director, Lauren Ball, Ph.D.)


Proteomics Center:  MALDI-Tissue Imaging Mass Spectrometry and Biomarker Discovery (Director and SmartState Chair, Rick Drake, Ph.D.; SmartState Chair, Anand Mehta, Ph.D.)

  • Bruker Solarix 7T FT-ICR Mass Spectrometer with MALDI-source for tissue imaging
  • Bruker Rapiflex MALDI-TOF-TOF Mass Spectrometer for high throughput tissue imaging


Name Role Phone Email Location
Jennifer Bethard
Lab Manager
CRI 309
Lauren Ball, Ph.D.
Director, Mass Spectrometry Facility
CRI 311
Richard Drake
Director, Proteomics Center



Search available services: View: by category alphabetically
Computational Proteomics (1)
MALDI Imaging (1)
Molecular Weight Determination (1)
PTM Quantitaton (2)
Protein Characterization (3)
Protein Identification (6)
Protein Quantitation (5)
unclassified (1)


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