Mass Spectrometry

Overview of Services

The MUSC Mass Spectrometry Facility provides expertise, services, education, and training to enhance biomedical research endeavors through LC-MS/MS-based proteomics. 

Services:  

LC-MS/MS for quantitative proteomics to for differential protein abundance, identification of differentially expressed nascent proteins, protein-protein or protein-drug interactions, phosphoproteomics.                     

ThermoScientific Orbitrap Elite ETD Mass Spectrometer interfaced to an Ultimate 3000 nanoLC system.

  • For protein identification, characterization of post-translational modifications, and quantitative proteomics using SILAC, TMT/iTRAQ, and label free approaches.   
  • Acquired through the NIH Shared Instrumenation Grant Program: S10D010731 Orbitrap Elite ETD Mass Spectrometer.  Please cite and link the grant to your publications on MyNCBI Bibliography.

       

 

MALDI-TOF Mass Spectrometry for intact proteins or peptides.

Bruker Autoflex III MALDI-TOF

 Related image

 

 

Leadership

Director:  Lauren E. Ball, Ph.D.; 843-792-4513, ballle@musc.edu

Lab Manager:  Jennifer Bethard, M.S.; 843-792-8637, bethard@musc.edu

Susana Comte-Walters, M.S.  

Kim Norris-Caneda, M.S.


Location and hours of operation

Hours Location

Available for consults Wednesday 1:00PM, CRI 311

To schedule email:ballle@musc.edu

Proteomics Center

305 Children’s Research Institute

Charleston, SC 29425

Links and Resources

Redox Center:  SC Center of Biomedical Research Excellence in Oxidants, Redox Balance and Signaling (P20 GM103542, PI:Tew)‑ Proteomics Core (Director, Lauren Ball, Ph.D.)

 

Proteomics Center:  MALDI-Tissue Imaging Mass Spectrometry and Biomarker Discovery (Director and SmartState Chair, Rick Drake, Ph.D.; SmartState Chair, Anand Mehta, Ph.D.)

  • Bruker Solarix 7T FT-ICR Mass Spectrometer with MALDI-source for tissue imaging
  • Bruker Rapiflex MALDI-TOF-TOF Mass Spectrometer for high throughput tissue imaging

Contacts

Name Role Phone Email Location
Jennifer Bethard
Lab Manager
 
843-792-8637
 
bethard@musc.edu
 
CRI 309
 
Lauren Ball, Ph.D.
Director, Mass Spectrometry Facility
 
843-792-4513
 
ballle@musc.edu
 
CRI 311
 
Richard Drake
Director, Proteomics Center
 

 
draker@musc.edu
 

 

Services


Search available services: View: by category alphabetically
Computational Proteomics (1)
MALDI Imaging (1)
Molecular Weight Determination (1)
PTM Quantitaton (2)
Protein Characterization (3)
Protein Identification (6)
Protein Quantitation (5)
unclassified (1)


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